OPEN-ACCESS PEER-REVIEWED
1N. Jagannath, 2Dr. D. Sheela, 3Dr.Rohit Dixit
1PhD Scholar, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha deemed university, Thandalam, Chennai.602105
2Associate Professor, Deptartmentof Pharmacology, Saveetha Institute of Medical and Technical Sciences, (SIMATS), Saveetha deemed university, Thandalam, Chennai.602105
3Professor, Department of Pharmacology, S.V.S medical college, Mahabubnagar, Telangana.
Abstract
Nature provides anabundant source of medicines that can be used to treat diabetes. A rangesecondary metabolites, including alkaloids, terpenoids and flavonoidshave shown notable anti-diabetic effects. These natural compounds can increase insulin secretion, boost insulin sensitivity, and lower blood glucose levels.Coccinia grandis (ivy gourd) have demonstrated promising potential in the field of medicine due to their rich phytochemical composition. Various cultural settings have traditionally utilized these herbs for their purported therapeutic properties, particularly in the field of diabetes management.Objective: The present studyobjective is to investigate the antidiabetic potential of Hydroalcoholic extract Coccinia grandis fruit through in vitro assays with DPP-IV enzyme inhibition and quantitative estimation with standard producers.Materials and Methods: The current research investigated DPP-IV inhibitory mechanism of C.Grandisfruit extract by utilizingthe spectrophotometric approachand Sitagliptin serves as a positive control. The efficacy of inhibition has beenevaluated by percent inhibition. Results: The findings indicated that the extract effectively suppressed DPP-IV activity, comparable to sitagliptin but at a concentration that was ten times greater. The extract exhibited IC50 value of 88.22μg/mL, whereasthe IC50 value of sitagliptin was 44.68μg/ml. The total flavonoid, phenolic,and alkaloid content in the fruit of coccinia grandis was measured to be 3.15 mg/100mg, 2.24mg/100mg,and 2.14 mg/100 respectively.Conclusion: the results indicate that the Hydroalcoholic extract of coccinia grandis hashigher flavonoid content compared to alkaloidsand phenols which may havea potential DPP-IV inhibitory effect thatcan serve potential anti-diabetic agent.
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