OPEN-ACCESS PEER-REVIEWED
1A. Naga Teja Pavani, 2Dr.D. Sheela, 3Dr. L. Ramesh
1PhD Scholar, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha deemed university, Thandalam, Chennai.602105
2Associate Professor, Dept of Pharmacology, Saveetha Institute of Medical and Technical Sciences, (SIMATS), Saveetha deemed university, Thandalam, Chennai.602105
3Professor of Pharmacology, Xavier University of Medicine. Aruba
Abstract
Kalanchoe pinnata, a widely recognized medicinal plant, has been traditionally used for various therapeutic purposes. This study aims to conduct a quantitative analysis and evaluate the acute toxicity of Kalanchoe pinnata to establish its safety profile. The quantitative analysis was performed to determine the concentration of key phytochemicals, including flavonoids, phenols, and alkaloids. These bioactive compounds were quantified to understand their potential therapeutic benefits.
For the acute toxicity study, Wistar rats were administered a single dose 2000mg/kgbw of Kalanchoe pinnata extract orally. Observations were made over a 14-day period to monitor any signs of toxicity, including changes in behaviour, body weight, and mortality. Gross histopathological examinations of vital organs such as the liver, kidney, and heart were conducted to assess any toxic effects.
The quantitative analysis revealed significant concentrations of flavonoids and phenols, suggesting potential antioxidant and anti-inflammatory properties. The acute toxicity study indicated that Kalanchoe pinnata extract is safe at doses up to 2000 mg/kg body weight, as no adverse effects or mortality were observed. Gross histopathological examination showed no significant tissue damage.
In this study, we analysed a plant species known for their medicinal properties to determine their phytochemical content using hydroalcoholic solvent to extract various compounds from these plants. This plant was found to contain alkaloids, flavonoids, and phenols.The observed results clearly confirmed the rich content of active phytoconstituents in the Kalanchoe pinnata leaf extract. The active components in plant were Flavonoids and satisfactory composition of alkaloids and Phenols and Terpenoids in both extracts.
In conclusion, the findings suggest that Kalanchoe pinnata is a promising candidate for further pharmacological studies due to its rich phytochemical profile and lack of acute toxicity. These results support its traditional use and provide a basis for its safe application in therapeutic settings.
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