OPEN-ACCESS PEER-REVIEWED
1Jyoti Joshi, 2Anjali Kannojiya, 3Kapil Kalra, 4Jyoti Maithani Kalra
1Department of Pharmacy, Alpine College of Management and Technology, Dehradun (U.K)
2Department of Pharmacy, Alpine College of Management and Technology, Dehradun (U.K)
3Department of Pharmacy, Alpine College of Management and Technology, Dehradun (U.K)
4School of Pharmaceutical Sciences, SGRR University, Dehradun (UK)
Abstract
Aim of the proposed research was to enhance the solubility of the drug Piroxicam by using natural and synthetic hydrotropes. Hydrotropy is a simple, effective and green platform of solubilization in which the chemical components known as hydrotropic solubilize the hydrophobic compounds in aqueous medium. Mixed hydrotropic phenomenon utilizes blends of hydrotropic agents which is taken in combination by using synthetic and natural hydrotropic agents for shows synergetic enhancement effect on solubility of poorly water soluble drugs. Piroxicam is a non steroidal anti-inflammatory drug, belonging to BCS Class II characterized by their low solubility and high permeability, which were chosen as a model drug in order to enhance its solubility by using hydrotropic technique. In this study, solubility of piroxicam was determined in individual hydrotropes as well as in different combinations of hydrotropic blend. The blends included HB 1 (sodium benzoate+ Piperazine), HB 2 (sodium benzoate+nicotinamide). These blends were taken in the ratio of 1:1, 1:2 and 1:3. And the solubility of piroxicam was determined. The HB 1 was used to prepare solid dispersion SD 1 (1:3), SD 2(1:6), SD 3 (1:9), SD 4 (1:12), SD 5 (1:15) and SD 6 (1:18) by the addition of drug in a clear solution of hydrotropic blend in water followed by its evaporation technique to produce a crystalline form. The solid dispersion were further formulated in capsules and then optimized and evaluated for dissolution, weight variation and solid state characterization by DSC and XRD.
Keywords: Hydrotropy, Solublization, BCS, Solid Dispersion, Dissolution.
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