OPEN-ACCESS PEER-REVIEWED
S.T. Gopu kumar1*, Eswari beeram2, Mrs. Sameera Begum3, Priyadarshini Chatterjee4, Debojit Samajdar5
1Centre for Global Health Research (CGHR), Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences (SIMATS), Saveetha University, Chennai – 602 105, Tamil Nadu, India.
2Assistant Professor, Department of Biological and Chemical sciences, School of Liberal arts and science Mohan Babu University
3Assistant Professor, Lords Institute of Engineering and Technology
4Asst Professor, Department of Computer Science and Engineering, B V Raju Institute of Technology, Narsapur, Medak, Hyderabad
5M. Pharm in Pharmaceutical Chemistry,Department of Pharmaceutical Chemistry, BCDA College of Pharmacy & Technology, 78/1 Jessore Road (S), Hridaypur, Kolkata-700127, West Bengal
Abstract
Volatile organic compounds (VOCs) are used in medical diagnosis and pharmaceutical analysis because they are found in biological fluids and pharmaceutical preparations.s. The most common method of VOC analysis is SPME-GC-MS due to its high sensitivity and low sample preparation. New developments in SPME particularly the use of fibers with nanoparticles enhance the extraction of VOCs. This work improved the SPME-GC/MS method by employing nanoparticle-coated fibers for the analysis of VOCs in medicinal and pharmaceutical samples. A comparison between the normal and the nano particle-coated SPME fibers was also done in detail. VOC profiling includes breath, urine, drug formulations, and other biological and pharmaceutical samples. A comparison of VOCs in the USA, Europe, and Asia was also done to determine the differences in the three regions. The results indicated that extraction efficiency improved when fibers were coated with nanoparticles, particularly for low-concentration VOCs in real sample matrices. The study also revealed that VOCs were different in the region and varied with the environment and lifestyle. The method was deemed reliable and consistent with a clear distinction of VOC profiles related to specific diseases and drug quality. The enhanced SPME-GC/MS technique employing nanoparticle-coated fibers is a potential technique for the detection of VOCs in medical diagnosis and pharmaceutical sectors. Due to the higher sensitivity and non-destructive nature of the technique, it may be employed in future clinical and industrial studies.
Keywords: Volatile Organic Compounds, SPME, Gas Chromatography-Mass Spectrometry, Nanoparticle-Coated Fibers, Medical Diagnostics, Pharmaceutical Quality Control.
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