OPEN-ACCESS PEER-REVIEWED
Anuj Pathak1, Satish Kumar Sharma2
1Professor & Dean, Glocal School of Pharmacy, Glocal School of Pharmacy, Glocal University, Delhi-Yamunotri Marg (State Highway 57), Mirzapur Pole, Distt – Saharanpur, U.P. – 247121, India
2Dept of Pharmaceutics, KIET School of Pharmacy, KIET Group of Institutions, Ghaziabad, India. 201206
Abstract
Nifedipine, classified as a dihydropyridine subclass within calcium channel blockers, is primarily employed as an antihypertensive and antianginal agent. In the setting of persistent stable angina, the IMAGE trial demonstrated a reduction in angina frequency and an increase in mean exercise duration with Nifedipine. To enhance its bioavailability, particularly through selective absorption in the upper gastrointestinal tract, it is recommended to develop a drug delivery system characterized by its ability to adhere to mucosal surfaces and release medication over an extended period in a sustained manner. In pursuit of this, a mucoadhesive tablet was formulated utilizing chitosan, guar gum, and HPMC as polymers. Mucoadhesion plays a crucial role in the tablet’s design, encompassing wetting, adsorption, and interpenetration of polymer chains. The different tablet formulations were assessed for total mucoadhesion time, buoyancy lag time, and the percentage of drug release. The results indicated diverse release kinetics influenced by the integration of different polymers and excipients. Comprehending the behaviors of these polymers greatly improved the precision of drug targeting. Examination of the data revealed a combination of release mechanisms, including erosion, diffusion, and swelling. The study’s comprehensive insights contribute valuable information regarding dosage form behavior and the impact of polymers on drug release. Notably, the optimized formulation exhibited superior outcomes, suggesting its potential utility for prolonged drug release in the stomach, thereby improving bioavailability and reducing dosing frequency. The drug release mechanism from the optimized formulation was confirmed as non-Fickian transport through the Higuchi pattern.
Keywords: Box-Behnken Design, Mucoadhesive tablet, Nifedipine, Stability, Antihypertensive, non-Fickian transport
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