OPEN-ACCESS PEER-REVIEWED
1K. Senthilkumar1, 2*A. Vijayalakshmi
1Ph. D Scholar, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai 600117, Tamil Nadu, India.
2*Professor, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Pallavaram, Chennai 600117, Tamil Nadu, India.
Abstract
Oral care cosmetic products are used to cleanse the oral cavity, freshen the breath, and maintain good oral hygiene. As the dental industry expands day by day, numerous types of oral care products are available on the market, including toothbrushes, toothpaste, mouthwash, floss, and whitening agents. Among these, toothbrushes and toothpaste are the most widely used oral care products. The microbiological protection of oral care cosmetics is of extreme importance in the industry because microbial contamination can harm the product, damage the skin, or introduce pathogens to injured skin, endangering the consumer’s health and spreading infection. Preservatives are antimicrobial compounds included in cosmetics to shield them from microbial infections brought on by ingredients, manufacturing processes, and user interaction. Despite the effectiveness of chemical preservatives in preventing microbial growth and extending shelf life, an increasing number of consumers are beginning to doubt their safety. As a result, there is growing interest in cosmetics that are self-preserving or preservative-free. The use of multifunctional ingredients with antimicrobial capabilities as alternatives to conventional preservatives has been studied. This article reports on the formulation of self-preserving oral care cosmeceutical products using multifunctional ingredients and other cosmetic ingredients. We identified ternary mixtures of multifunctional actives that act synergistically and validated the potential of these formulations to deliver microbiologically safe, self-preserving products equivalent to those preserved with approved preservatives. Glyceryl caprylate, inulin, and zinc lactate in the ratios of 1:6.3:1.3, 0.5:12.5:35 and 1:12.5:35 showed a synergistic interaction. Anti-decay toothpaste, anti-decay tooth gel, and anti- decay mouth rinse dosed with these formulations at 0.5% and 0.75% were prepared. The treated cosmeceutical personal care formulations were compared against approved conventional preservative and non-preserved formulations. All three antimicrobial compositions were effective in preserving the cosmetic formulations for up to 28 days (PCT study).
Keywords: antimicrobial, self-preservation, oral care formulations, conventional preservatives,
multifunctional ingredients.
References
[1]. Junaid A.B., Khan M.I., Mansoori M.U., Zameer M., Ali S.J. (2012) To identify various parameters leading to the growth of dental care products in the Indian market. IOSR J. Bus. Manage. 4: 4– 12.
[2]. Agrawal A., Gupta A. (2020) Exploring the Factors Influencing the Choice of Oral Care Products: A Review on Personalized Approach. Int J Oral Dent Health. 6:109.
[3]. Croshaw B. E. T. T. Y.(1977) Preservatives for cosmetics and toiletries. J. Soc. Cosmet. Chem. 28, 3- 16.
[4]. William R., Philip A., Matzin T, Arthur F.(1977) Preservation of cosmetic lotions with imidazolidinyl urea plus parabens. J. Soc. Cosmet. Chem, 28, 83–87.
[5]. DeBaun D., Hoyle R., Weinstein S.(2014) Natural preservative alternatives and compositions containing same. U.S. Patent No. 8,623,430. Woodcliff Skincare Solutions Inc.
[6]. Devlieghere F, Loy‐Hendrickx A. D, Rademaker M, Pipelers P, Crozier A, Baets B. D, Keromen S. (2015) A new protocol for evaluating the efficacy of some dispensing systems for packaging in the microbial protection of water- based preservative-free cosmetic products Int. Jour. Cosmet. Sci. 37(6), 627–635.
[7]. Kabara J.J., Orth D.S. (1977) Preservative-Free and Self-Preserving Cosmetics and Drugs: Principles and Practice (Marcel Dekker, New York)
[8]. Meenakshi N, Sekar P, Pasupathi M, Mukhopadhyay M (2016) Self-preserving skin care cosmetic products. Int. J. Adv. Biotechnol. Res., 7(1), 22-3.
[9]. CLSI Reference Method for Susceptibility Testing of Yeasts, Approved Standard, Third Edition CLSI document M27-A3, Vol. 28, No. 14Wayne,PA: Clinical and Laboratory Standards Institute & Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard, Tenth Edition. CLSI document M07-A10, Vol. 35, No. 2 Wayne,PA: Clinical and Laboratory Standards Institute(2008 & 2015).
[10]. Kull A.C., Eisman, P.C., Sylwestrowicz, H.D., and Mayer R.L. (1961) Applied Microbiology, 9: 538–541.
[11]. CTFA Microbiology Guidelines (1993) Ed. Curry A.S., Graf J.G., and McEven G.N.
[12]. ISO 11930:2019 (2019) Cosmetics-Microbiology Evaluation of the antimicrobial protection of a cosmetic product
[13]. Bergasson G, Arnfi nnsson J, Steingrìmson O, Thormar H (2001) In vitro killing of Candida albicans by fatty acids and monoglycerides, Antimicrob. Agents Chemother., 45, 3209–3212
[14]. Rigano L, Leporatt R (2003) Systemic constellations: With or without preservatives? SOWF J., 129, 1–9.
[15]. Janichen J. (2004) The quest for the ideal preserving system-reducing traditional preservatives in combination with Dermosoft Octiol Euro Cosmetics, 7/8, 10–16.
[16]. Noureddine H., Isabel P.F., Sandrina A.H., Patricia C., Zahia B.O., Kebir B., Alirio E.R., Isabel C.F.R.F., Maria F.B. (2018) Cosmetics Preservation: A Review on Present Strategies Molecules,23, 1571-1612.
[17]. Kabara J.J., Swieczkowski D.M., Conley A.J., and Truant J.P. (1972), Fatty acids and derivatives as antimicrobial agents, Antimicrob. Agents Chemother., 2, 23–28.
[18]. Anelich L.E., Korsten L. (1996) Survey of microorganisms associated with spoilage of cosmetic creams manufactured in South Africa., Int. J. Cosmet, Sci., 18, 25–40.
[19]. Campana R., Scesa C., Patrone V., Vittoria E., and Baffone W., (2006) Microbiological study of cosmetic products during their use by consumers: Health risk and efficacy of preservative systems, Lett. Appl. Microbiol., 43, 301–306.
[20]. Whitby D., Roth B.C. (2010): challenging times for preservation Personal Care, 28–29.
[21]. Kabara J.J. (1999) Hurdle technology: Are biocides always necessary for product protection? J. Appl. Cosmetol. 17,102 –108.
[22]. Stoffels K.M. (2012) Modern and safe antimicrobial stabilization of cosmetic products. Household and personal care today. 7, 18 – 21.